Derivation and external validation of community-acquired pneumonia subphenotypes in Southeast Asia: a secondary analysis of prospective cohort studies.

ABSTRACT:

Background

Identifying pneumonia subphenotypes in understudied populations can advance equitable personalized medicine for pneumonia care. We aimed to derive and validate subphenotypes of patients presenting with community-acquired pneumonia (CAP) in Southeast Asia.

Methods

This secondary analysis included three prospective cohorts conducted between March 2013 and April 2020. First, we performed latent class analysis to identify subphenotypes using clinical and laboratory variables in a prospective cohort of adults hospitalized with CAP in northeastern Thailand. Next, we compared clinical and biological features between the subphenotypes and then developed a parsimonious classifier model (PCM) for accurate subphenotype assignment. We then validated the accuracy of PCM subphe

SUBMITTER: Coston TD 

PROVIDER: S-EPMC12595281 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature