Impact of Subcutaneous Adipose Tissue Index Change During Neoadjuvant Chemoradiotherapy on Disease-Free Survival and Tumor Response in Patients with Locally Advanced Rectal Cancer.

ABSTRACT: Background & Aims: The heterogeneity among patients with locally advanced rectal cancer (LARC) necessitates identifying predictive markers of response to neoadjuvant chemoradiotherapy (nCRT) to enable personalized treatment strategies. Adipose tissue, which reflects nutritional status and chronic inflammation, has been implicated in tumorigenesis and disease progression. This study investigated the potential of adipose tissue as a predictive marker of nCRT response and prognosis in patients with LARC. Methods: We analyzed pre- and post-nCRT non-contrast computed tomography images at the third lumbar vertebral level to quantify adipose tissue in patients with LARC. We examined the relationship between changes in the subcutaneous adipose tissue index (SATI) and treatment outcom

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12595343 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature