Association Between Intrauterine Growth Restriction and Chronic Kidney Disease: A Birth Cohort Study Analysis.

ABSTRACT:

Rationale & objective

Diabetes mellitus and hypertension are the main risk factors for chronic kidney disease (CKD), but factors affecting fetal development also contribute to later kidney loss. Various birth-related factors and definitions, including low birth weight (LBW), intrauterine growth restriction (IUGR), and prematurity, complicate the understanding of this relationship. Therefore, this study aimed to evaluate the effect of these fetal conditions on the risk of CKD by the end of the third decade of life.

Study design

A single-center, birth cohort study.

Setting & participants

The cohort was established between 1978 and 1979 in Brazil, which included 6,827 newborns (98% of births). The follow-up visit occurred in 2016/2017, and 1,564 participants were include

SUBMITTER: Lorencini DA 

PROVIDER: S-EPMC12595368 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature