Associations of Plasma and Urine Uromodulin With Kidney Disease Progression in Persons With Chronic Kidney Disease and Hypertension: The Systolic Blood Pressure Intervention Trial.

ABSTRACT:

Rationale & objective

Uromodulin (UMOD) is a kidney tubule biomarker that can be measured in blood and urine and may help identify persons with chronic kidney disease (CKD) at greater risk of progression. Whether blood or urine UMOD is more strongly associated with CKD progression is unknown.

Study design

This was a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), in which an intensive systolic blood pressure target reduced risk of cardiovascular events and mortality.

Setting & population

A total of 2,302 SPRINT participants with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m².

Exposures

Plasma and urine UMOD measured at baseline.

Outcomes

Acute kidney injury, 30% decline in eGFR, end-stage kidn

SUBMITTER: Ikeme JC 

PROVIDER: S-EPMC12595371 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature