Association Between Relapse and Long-Term Kidney Outcomes in IgA Nephropathy.

ABSTRACT:

Rationale & objective

Relapse in IgA nephropathy (IgAN) remains under-researched. This study investigates the incidence of IgAN relapse, its association with adverse outcomes, and its risk factors within a prospective cohort.

Study design

Prospective cohort study.

Setting & participants

The study included 1,069 patients with IgAN who achieved remission following treatment.

Predictor

Relapse or not after remission of IgAN.

Outcomes

The first occurrence of either end-stage kidney disease (estimated glomerular filtration rate [eGFR] <15 mL/min/1.73 m², dialysis, or kidney transplantation) or a 50% decline in eGFR.

Analytical approach

We assessed relapse incidence, its correlation with kidney endpoint events, and identified clinicopathologi

SUBMITTER: Shen X 

PROVIDER: S-EPMC12595374 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature