Natural History of Advanced Primary Hyperoxaluria Type 1: A Retrospective Study.

ABSTRACT:

Rationale & objective

Characterize the natural history of advanced primary hyperoxaluria type 1 (PH1) in a multinational patient cohort.

Study design

A retrospective chart review.

Setting & participants

Patients, from participating medical centers in North America, Europe, and the Middle East, had ≥ 4 health care visits related to PH1 spanning ≥ 6 months (except deceased patients) on/after January 1, 2000, and ≥ 2 estimated glomerular filtration rate (eGFR) values ≤ 45 mL/min/1.73m² (if age < 12 months, 2 serum creatinine values elevated for age) were included.

Exposure

None (retrospective observational study).

Outcomes

Kidney function, liver and/or kidney transplantation, death, plasma oxalate, systemic oxalosis, emergent clinical events, and

SUBMITTER: Lieske JC 

PROVIDER: S-EPMC12595380 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature