Asymmetric mitonuclear interactions trigger transgressive inheritance and mitochondria-dependent heterosis in hybrids of the model system <i>Pleurotus ostreatus</i>.

ABSTRACT: Mitonuclear interactions are crucial in governing mitochondrial function, development and responses to stress in eukaryotic organisms. In this study, we explored how varying mitochondrial haplotypes affect the phenotype and oxidative stress response using hybrids of the basidiomycete Pleurotus ostreatus (P. ostreatus) as a model system. By performing reciprocal crosses between monokaryotic strains with distinct nuclear and mitochondrial genomes, we identified notable differences in growth rates, accumulation of reactive oxygen species (ROS) and gene expression patterns. Hybrids with incompatible mitonuclear combinations displayed slower growth and elevated expression of genes - some showing transgressive inheritance - associated with the Electron Transport Chain (ETC) and ant

SUBMITTER: Garde E 

PROVIDER: S-EPMC12595512 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature