MYEOV Is a Novel Marker of Differentiated Corneal Epithelium.

ABSTRACT:

Purpose

Myeloma overexpressed gene (MYEOV) was initially identified as a gene amplified in several malignancies and was found to promote cell proliferation and metastasis. Our previous comparative RNA sequencing and epigenetic analyses revealed high MYEOV levels in differentiated corneal epithelial cells and showed that TET2 epigenetically regulated MYEOV expression. In the current study, we aimed to further characterize the expression and regulation of MYEOV in the human ocular surface.

Methods

MYEOV expression was examined by immunostaining of the human corneas and by analysis of the publicly available single-cell RNA sequencing data. Gene knockdown (KD) of MYEOV and the regulators of corneal epithelial differentiation, PAX6 and KLF4, in in vitro-expanded corneal epithelia

SUBMITTER: Fukuda Y 

PROVIDER: S-EPMC12595593 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature