Complementary Roles of DNA Methylation and miRNA in Regulating Gene Expression Under Environmental Stress in Biological Invasions.

ABSTRACT: Biological invasions significantly threaten global biodiversity and disrupt the stability of ecosystems worldwide. Effective responses to environmental stressors are crucial for invasion success; however, the underlying epigenetic regulatory mechanisms remain poorly understood, especially regarding the interplay among multiple regulatory layers such as DNA methylation and microRNAs (miRNAs). Here we employed an integrative multi-omics approach to investigate the model invasive Ciona robusta subjected to repeated salinity stress. Focusing on canonical osmotic regulation pathways, we revealed a dynamic and coordinated regulation of stress-responsive gene expression, with miRNAs and DNA methylation playing distinct yet complementary roles across functional pathways/genes and distinct r

SUBMITTER: Yan W 

PROVIDER: S-EPMC12595603 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature