KDM3B suppresses castration-resistance prostate cancer cell proliferation by promoting PTEN expression.

ABSTRACT:

Background

Castration-resistant prostate cancer (CRPC) represents the terminal stage of prostate cancer (PCa), yet the molecular mechanisms driving its development remain unclear. Members of the histone lysine demethylase (KDM) family regulate histone methylation and thereby modulate transcriptional programs during malignant progression, contributing to PCa pathogenesis. While the function of KDM3B in PCa has been described, its involvement in CRPC remains uncertain. This study investigated the mechanistic role of KDM3B in CRPC progression.

Methods

Clinical specimens and publicly available datasets were analyzed to assess KDM3B expression in PCa and CRPC tissues. Cellular proliferation was evaluated through CCK-8 and colony formation assays. In addition, RT-PCR, WB, and CCK-

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12595770 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature