Harnessing NLRX1: a new frontier in mitigating inflammation in pulmonary hypertension.

ABSTRACT:

Background

Hypoxic pulmonary hypertension (HPH) serves as a crucial link in the pathogenesis of chronic high-altitude diseases and chronic obstructive pulmonary disease (COPD), and ultimately may lead to right heart failure. Hypoxia triggers immune responses and inflammatory processes, which contribute to vascular remodeling and elevated pulmonary artery pressure. NLRX1, a member of the Nod-like receptor family, plays a significant regulatory role in immunity, antioxidation, and apoptosis. However, its role in the occurrence and development of HPH remains unknown.

Methods

Wild type (WT) C57BL/6 mice and NLRX1 knockout (NLRX1^-/-) Mice were subjected to intermittent chronic hypoxia for 6 weeks to establish a hypoxic pulmonary hypertension model that is similar to th

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12595859 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature