Association between plasma extracellular vesicles LncRNAs and metabolic syndrome in polycystic ovary syndrome.

ABSTRACT:

Background

This case-control study aimed to investigate the relationship between plasma EVs LncRNAs, specifically Xist, MALAT1, and NEAT1, and MetS in PCOS patients, to identify a novel biomarker for early MetS diagnosis in these patients.

Methods

The levels of Xist, MALAT1, and NEAT1 in PCOS patients with and without MetS were quantified using qRT-PCR and then compared. Generalized linear regression and trend regression analyses were utilized to examine the association between three LncRNAs and MetS. ROC curve, DCA, AIC assessment, and importance ranking were applied to assess the clinical value of the three LncRNAs for MetS in PCOS patients.

Results

The study included 220 newly diagnosed PCOS patients, with 82 (37.273%) having MetS. The expression levels of Xist, MA

SUBMITTER: Wu YZ 

PROVIDER: S-EPMC12595885 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature