Sequential Combination of Unfavorable Histology, Followed by Clinical Stage M, Defines High-Risk Neuroblastoma: A Report from the Children's Oncology Group.

ABSTRACT:

Purpose

Historically, neuroblastoma risk stratification has been performed with clinical stage as the starting point and successively adding other prognostic factors thereafter. This study takes an alternative approach to define risk groups of patients with neuroblastoma by starting with the International Neuroblastoma Pathology Classification (INPC).

Experimental design

The cohort of patients with neuroblastoma previously used for developing the Children's Oncology Group-Revised Neuroblastoma Risk Classification (RNRC) system was reanalyzed by survival tree regression analysis, starting with the INPC distinguishing favorable-histology and unfavorable-histology categories. The resultant two branches were further divided first by the International Neuroblastoma Risk Group Sta

SUBMITTER: Hazard FK 

PROVIDER: S-EPMC12596000 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature