OncotreeVIS-an interactive graphical user interface for visualizing mutation tree cohorts.

ABSTRACT:

Summary

In recent years, developments in single-cell next-generation sequencing technology and computational methodology have made it possible to reconstruct, with increasing precision, the evolutionary history of tumors and their cell phylogenies, represented as mutation trees. Many mutation tree inference tools exist, but they do not support detailed visual tree inspection, nor tree comparisons or analysis at the cohort level, an important task in computational oncology. We developed oncotreeVIS, an interactive graphical user interface for visualizing mutation tree cohorts and tree posterior distributions obtained from mutation tree inference tools. OncotreeVIS can display mutation trees that encode single or joint genetic events, such as point mutations and copy number changes,

SUBMITTER: Baciu-Dragan MA 

PROVIDER: S-EPMC12596139 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature