Urinary endotrophin as a biomarker for T cell-mediated rejection-associated fibrogenesis in kidney transplant recipients.

ABSTRACT:

Background

Endotrophin, a C-terminal pro-collagen type VIα3 fragment, has been shown to correlate with kidney interstitial fibrosis, kidney outcome measures and survival in various kidney diseases and kidney transplantation. In this study we investigated whether endotrophin is associated with fibrogenesis in T cell-mediated rejection (TCMR), allowing its use as a non-invasive biomarker.

Method

Plasma endotrophin and urinary endotrophin (indexed for creatinine) were measured in samples from a cross-sectional study among kidney transplant recipients (KTRs) who underwent indication biopsy after transplantation and enrolled in TransplantLines Biobank and Cohort Study. Endotrophin was measured using the nordicPRO-C6 enzyme-linked immunosorbent assay. Blood and urine were collecte

SUBMITTER: Alkaff FF 

PROVIDER: S-EPMC12596184 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature