Polydopamine-chitosan coated biofilm-state <i>Lacticaseibacillus paracasei</i> SB27 as a living band-aid for targeted colitis therapy.

ABSTRACT: Inflammatory bowel disease (IBD) involves chronic intestinal inflammation and epithelial barrier disruption. While probiotics offer therapeutic potential, planktonic (PLA) forms suffer from poor viability, limited adhesion, and suboptimal efficacy. Biofilm-state (BIO) probiotics can exert probiotic functions effectively, yet inflammation impairs the conditions necessary for probiotics to form biofilm in the intestine. Direct delivery of biofilm-state probiotics offers a more effective strategy. Here, an innovative probiotic targeted delivery system is developed by integrating biofilm-state Lacticaseibacillus paracasei SB27 with a rationally designed dual-coating composed of polydopamine (PDA) and chitosan (CS) (BIO@PCS). This system enables pH-responsive release of probiotics and se

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12596216 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature