Preventing effect of plant extracts and omega-3 on age-related cognitive decline in male mice.

ABSTRACT:

Background

Aging is associated with cognitive decline, accompanied by neuroinflammation, oxidative stress, impaired synaptic plasticity, and gut microbiota dysbiosis. Nutritional interventions, specifically those rich in polyphenols, carotenoids, and omega-3 (om-3) fatty acids, have demonstrated potential benefits in preventing age-related cognitive decline. This study investigates the combined effects of plant extracts (PE) including polyphenols and carotenoids, and fish oil containing om-3 on cognitive function and underlying biological processes in aged mice.

Objectives

To assess the impact of PE and om-3, alone and in combination, on age-related cognitive decline, especially on memory outcomes and to highlight mechanisms involved in these effects.

Methods

17-month

SUBMITTER: Martin M 

PROVIDER: S-EPMC12596225 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature