Predictors and nomogram for upstaging to invasive breast carcinoma in ductal carcinoma <i>in situ</i> diagnosed by ultrasound-guided core needle biopsy.

ABSTRACT:

Background

Ductal carcinoma in situ (DCIS) cases diagnosed by ultrasound-guided core needle biopsy (US-CNB) carry a risk of postoperative upstaging to invasive breast carcinoma, complicating clinical management. This study aimed to investigate clinicopathological and ultrasound (US) predictors for postoperative upstaging and to develop a nomogram for individualized risk prediction.

Methods

A total of 240 patients with 246 DCIS lesions diagnosed by US-CNB were enrolled in this retrospective study from May 2013 to January 2025. Clinicopathological and US features were compared using the Student's t-test for continuous variables and the Chi-squared or Fisher's exact test for categorical variables. Multivariate logistic regression identified predictors of upstaging to DCI

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12596424 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature