Serum immunoglobulin G glycosylation profiling in breast cancer using a 56-lectin microarray and subtype-specific patterns.

ABSTRACT:

Background

Protein glycosylation is the enzymatic addition of sugar chains to specific protein sites and part of this process has a crucial functional modification associated with carcinogenesis and cancer progression. This study aimed to profile and confirm aberrant immunoglobulin G (IgG) protein glycosylation in sera obtained from individuals with breast cancer (BC), with emphasis on breadth of lectin panel and subtype-specific patterns.

Methods

A total of 185 sera underwent lectin microarray analysis with 56 lectins. Validation was performed on sera from an additional 20 BC patients and 6 healthy controls.

Results

Differential binding intensities of IgG glycans to Agaricus bisporus lectins (ABA) and Salvia sclarea (SSA) were observed between BC patients and healthy

SUBMITTER: Peng L 

PROVIDER: S-EPMC12596431 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature