Cutaneous microcirculatory disturbances are reversible in the early post-resuscitation period after asphyxial cardiac arrest.

ABSTRACT:

Background

Despite successful resuscitation from cardiac arrest (CA), patients often develop a fatal post-resuscitation syndrome due to ischemia-reperfusion injury. The disruption of hemodynamic coherence, where restored macrocirculation fails to improve microcirculation, leads to persistent tissue hypoperfusion and organ failure, making early non-invasive assessment of the microvasculature crucial for detecting these post-resuscitation disturbances. This study aimed to identify markers of peripheral circulatory disturbances in the early post-resuscitation period after asphyxial CA in rats.

Methods

The study was performed on adult male Wistar rats randomized into two groups: group I-sham operated animals (Sham group), group II-asphyxial CA followed by resuscitation (CA group

SUBMITTER: Dubensky A 

PROVIDER: S-EPMC12596470 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature