Prognostic value of the systemic immune-inflammation index in recurrent/metastatic triple-negative breast cancer: a retrospective cohort study.

ABSTRACT:

Background

Local relapse and distant metastasis are the primary causes of treatment failure and mortality in patients with breast cancer. Triple-negative breast cancer (TNBC) is characterized by limited treatment options, high rates of relapse and metastasis, and poor survival rates. This study aimed to explore the prognostic importance of the systemic immune-inflammation index (SII) among patients with recurrent/metastatic TNBC, focusing on the potential of SII as a novel biomarker for survival prediction.

Methods

This retrospective research involved 62 patients with recurrent/metastatic TNBC who received secondary surgery in Peking Union Medical College Hospital following primary surgery between 2005 and 2018. Clinical data on the preoperative SII, tumor characteristics, a

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12596502 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature