Comparison of direct oral anticoagulants and vitamin K antagonists in the treatment of left ventricular thrombi: a retrospective cohort study.

ABSTRACT:

Background

Left ventricular thrombus (LVT) is a serious thromboembolic complication in patients with cardiomyopathies. Evidence supporting direct oral anticoagulant (DOAC) therapy in LVT is limited.

Objectives

We evaluated the effectiveness and safety of DOACs compared with vitamin K antagonists (VKAs) in patients with LVT.

Methods

A multisite retrospective cohort study was performed, including patients with LVT diagnosed by echocardiography from 2018-2023 who were treated with either DOACs or VKAs. Primary outcome was the incidence of stroke and systemic embolism (SSE). Secondary outcomes included LVT resolution, major bleeding, and all-cause mortality.

Results

A total of 182 patients with LVT met inclusion criteria, of which 70 (38.5%) were treated with only

SUBMITTER: Elbenawi H 

PROVIDER: S-EPMC12596518 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature