Self-carrier nanodrugs with dual antibacterial agents to overcome tobramycin resistance in multidrug-resistant <i>Staphylococcus aureus</i>.

ABSTRACT: Multidrug-resistant (MDR) bacterial infections have emerged as a significant threat to global public health, with antibiotic resistance mechanisms-such as alterations in bacterial membrane permeability-substantially limiting therapeutic options and exacerbating infection persistence. In this study, we developed a novel self-carrier nanodrug formulation by directly assembling antibiotic tobramycin (Tob) and antimicrobial borneol 4-formylbenzoate (BF) into Tob-BF nanodrugs (TBN) via dynamic Schiff base linkages, without the need for additional adjuvants. The resultant TBN exhibits minimal bactericidal activity under physiological conditions but undergoes decomposition and activation specifically within the microenvironment of bacterial infections. Confocal microscopy analysis demonstr

SUBMITTER: Fu YN 

PROVIDER: S-EPMC12596677 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature