Topological and functional characterization of human translation efficiency covariation network.

ABSTRACT:

Motivation

Gene co-expression networks based on RNA abundance have identified genes with shared biological functions, common regulatory elements, and physical interactions among their protein products. Although thousands of ribosome profiling datasets are publicly available, they have not been leveraged to construct networks to characterize translation efficiency covariation (TEC) to quantify how translation of different transcripts co-varies across conditions.

Results

We construct and analyze a human TEC network, revealing topological and functional properties distinct from RNA co-expression networks. The TEC network displays modular structure, small-world characteristics, and rich-club organization but differs substantially in node connectivity and neighborhood composition

SUBMITTER: Qi K 

PROVIDER: S-EPMC12596699 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature