Study on the correlation between Interleukin 4 and febrile seizures.

ABSTRACT:

Objective

Febrile seizures (FS) are common in pediatric epilepsy, but their precise etiology remains unclear. Although cytokines such as interleukin (IL)-4, IL-1, and IL-6 are known to influence FS fever responses, their specific role is not fully understood. This study aimed to clarify the correlation between IL-4 levels and febrile convulsions, exploring molecular mechanisms through bioinformatics and animal experiments to enhance the understanding of FS pathogenesis.

Material and methods

With the GSE28674 dataset, the K-means clustering algorithm was used to select key genes that regulate IL-4 during feature selection. An animal model of FS was developed, and in vivo experiments were conducted using enzyme-linked immunosorbent assay, flow cytometry, quantitative po

SUBMITTER: Xiang X 

PROVIDER: S-EPMC12596810 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature