Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study.

ABSTRACT:

Background

Some observational studies have reported that sodium-glucose cotransporter 2 (SGLT2) inhibitors may have an impact on psychiatric disorders. This Mendelian randomization (MR) study aims to explore the causal relationship between SGLT2 inhibition and five types of psychiatric disorders.

Methods

Genetic variants associated with the SLC5A2 gene and glycated hemoglobin were selected from the eQTLGen Consortium and Genotype-Tissue Expression datasets. Type 2 diabetes served as a positive control in the application of MR and colocalization analyses to investigate potential causal relationships between SGLT2 inhibition and depression, anxiety disorder, schizophrenia, obsessive-compulsive disorder, and bipolar affective disorder. The impact of glycated hemoglobin on psych

SUBMITTER: Liu L 

PROVIDER: S-EPMC12596861 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature