Prognostic implications of microRNA-107 in esophageal cancer: a retrospective cohort study.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) imposes a heavy disease burden in China, accounting for over 50% of global cases and approximately 301,000 annual deaths. Current prognostic markers inadequately predict recurrence in early-stage patients. This study investigates microRNA-107 (miR-107) as a novel prognostic biomarker for ESCC.

Methods

Tumor tissues (n = 66) and adjacent normal tissues (n = 28) were collected from ESCC patients undergoing radical surgery (2010-2012). miR-107 expression was quantified via reverse transcription quantitative polymerase chain reaction (RT-qPCR) (normalized to U6 snRNA). Clinicopathological correlations and survival outcomes were analyzed using χ ² tests, Kaplan-Meier/log-rank tests, and Co

SUBMITTER: Sun J 

PROVIDER: S-EPMC12596877 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature