Long-term risk of venous thromboembolism following hip or knee replacement surgery: a population-based matched cohort study.

ABSTRACT:

Background

Hip or knee joint replacement (HJR or KJR) is linked to a short-term increased risk of venous thromboembolism (VTE), but evidence on long-term VTE risk beyond 1 year is limited. This study compared the 10-year VTE risk in HJR or KJR patients with the general population.

Methods

We conducted a prospective matched cohort study using the UK Biobank. A total of 18,984 HJR and 16,709 KJR patients were matched with controls by age, sex, VTE history, and cancer history via exposure density sampling. Flexible parametric models and piecewise Cox models were used to estimate time-varying hazard ratios (HRs) and 95% confidence intervals (CIs) for VTE over 10 years postsurgery.

Results

A total of 211,190 participants were included in the HJR cohort and 192,440 in the K

SUBMITTER: Wu P 

PROVIDER: S-EPMC12597009 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature