Fibrinolytic Capacity and Risk of Bleeding in Intensive Care Patients with Acute Kidney Injury.

ABSTRACT:

Background

Acute kidney injury (AKI) is common among intensive care unit (ICU) patients and is associated with increased bleeding risk. The impact of fibrinolysis in AKI-related bleeding has not been explored previously.

Objectives

(1) Compare fibrinolytic capacity in ICU patients with and without AKI. (2) Investigate the association between fibrinolytic capacity, as well as other laboratory and clinical variables, and bleeding within the first 7 ICU days in AKI patients.

Methods

Adult ICU patients were prospectively enrolled and stratified by AKI presence and severity at ICU admission. On the morning after admission, fibrinolytic capacity was assessed using a modified rotational thromboelastometry (ROTEM-tPA) assay. The primary outcome was the difference in ROTEM-tPA

SUBMITTER: Mikkelsen RR 

PROVIDER: S-EPMC12597085 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature