Association Between Physical Activity and the Risk of Dementia Among Patients With Depression: A Nationwide Cohort Study.

ABSTRACT:

Objective

This study investigates the impact of changes in physical activity (PA) on the risk of developing dementia in individuals diagnosed with depression, using a large-scale, retrospective national cohort dataset.

Methods

Using a cohort data from the National Health Insurance of South Korea, 1,291,706 clinically depressed subjects were analyzed to assess the relationship between PA and dementia onset. Subjects were classified into four groups-"never," "beginning," "discontinuation," or "maintenance"-based on their PA status before and after the diagnosis of depression. Hazard ratios with confidence intervals were calculated to determine the risk across different PA status groups.

Results

Among the total sample, 58,934 (4.56%) were newly diagnosed with dementia du

SUBMITTER: Yook VM 

PROVIDER: S-EPMC12597157 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature