AgamOBP1-Directed Discovery of Repellents to Control the Spread of Mosquito-Borne Diseases.

ABSTRACT: Toward the discovery of novel efficient repellents, protein-directed dynamic combinatorial chemistry (pdDCC) coupled to saturation-transfer difference (STD) NMR spectroscopy was initially employed to identify modulators of the malaria vector Anopheles gambiae Odorant Binding Protein 1 (AgamOBP1). A library of potential binders of AgamOBP1 (secondary amines) generated from two amines and seven aldehydes was designed aiming to enable interactions with critical amino acids at the DEET-site and to bridge the DEET- and Icaridin sIC-binding pockets, both implicated in repellents recognition. Solubility issues hindered the clear identification of binders among the DCL members, except for one sublibrary, leading us to shift our strategy towards the synthesis of the designed amines, followed by dir

SUBMITTER: Chazapi E 

PROVIDER: S-EPMC12597222 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature