Molecular Docking and Target-Specific Binding Profiles of Benzosuberane-Based Compounds.

ABSTRACT: Cancer, a leading cause of global mortality, is characterized by uncontrolled cell proliferation and remains a significant therapeutic challenge due to drug resistance and treatment failures. Despite advancements in targeted therapies, novel agents are still in strong demand. Benzosuberane, a bicyclic scaffold present in natural products such as colchicine and theaflavin, has emerged as a promising structural core in cancer therapeutics due to its structural flexibility and diverse biological activities, including antitumor, anti-inflammatory, and antimicrobial effects. This review consolidates the computational insights driving the design of benzosuberane-based compounds as effective antitumor agents. Focusing on molecular docking studies, it highlights the interaction profiles with vario

SUBMITTER: Saragatsis MA 

PROVIDER: S-EPMC12597223 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature