Relationship Between Platelet Aggregation and Clinical Events After Percutaneous Coronary Intervention for Dialysis Patients　- A PENDULUM Analysis Substudy.

ABSTRACT:

Background

Patients with endstage kidney disease undergoing hemodialysis (HD) have higher risks of ischemic and bleeding events after percutaneous coronary intervention (PCI). However, the association between high platelet reactivity (HPR) and clinical events in dialysis patients remains unclear. This post hoc analysis of the PENDULUM registry examined the relationships of HPR with major adverse cardiac and cerebrovascular events (MACCE) and major bleeding in dialysis patients.

Methods and results

Based on P2Y₁₂ reaction unit (PRU) levels, patients were stratified into HPR (PRU >208) and non-HPR (PRU ≤208) groups. Clinical events were assessed up to 30 months after the index PCI. A total of 6,266 patients were enrolled. Of the 5,907 patients with available PRU dat

SUBMITTER: Yoshiura D 

PROVIDER: S-EPMC12597243 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature