Perivascular spaces, diffusion MRI markers and cognitive decline in cerebral small vessel disease.

ABSTRACT:

Background

MRI markers, including visible perivascular spaces (PVS), diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, and peak width of skeletonized mean diffusivity (PSMD) may capture the earliest pathogenesis of cerebral small vessel disease (SVD). This study aimed to elucidate the association between these markers and cognitive decline in sporadic and hereditary SVD.

Methods

We included individuals from two cohorts: (1) participants with sporadic SVD from the Radboud University Nijmegen Diffusion tensor Magnetic resonance imaging Cohort (RUNDMC) and (2) participants with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) followed at the French National Referral Center. Individuals in both coho

SUBMITTER: Sole-Guardia G 

PROVIDER: S-EPMC12597285 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature