Prognostic value of tumor-infiltrating lymphocytes (TILs) in Luminal breast cancer: A novel computational method for assessing TILs abundance and spatial distribution patterns.

ABSTRACT: The prognostic significance of tumor-infiltrating lymphocytes (TILs) in Luminal-type breast cancer remains controversial, primarily due to typically low TIL infiltration levels, methodological inconsistencies in assessment, and insufficient consideration of spatial distribution patterns. To overcome these limitations, we developed an advanced artificial intelligence (AI)-driven computational TIL assessment (CTA) system, compliant with international visual assessment guidelines, which enables precise quantification of both TIL abundance (automatic TILs, aTILs) and spatial distribution patterns (aggregated: aTILs-agg; distributed: aTILs-dis) in Luminal-type breast cancer. Our comprehensive analysis suggests that elevated TIL levels were significantly associated with improved overall survival

SUBMITTER: Cai X 

PROVIDER: S-EPMC12597290 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature