Dynamic matrix engineering promotes nascent protein deposition to drive cell migration and expedite Re-epithelization in chronic wound.

ABSTRACT: Chronic wound healing remains a formidable clinical challenge, fundamentally hindered by stalled re-epithelialization caused by dysfunctional cell migration arising from a disordered mechano-biochemical microenvironment. Current therapeutic strategies relying on externally-assisted growth factors or mechanical stimulation often neglect the inherent capacity of the native, dynamic extracellular matrix (ECM) to govern cell behavior, specifically its viscoelasticity. By engineering a reversible hydrazone-crosslinked lysozyme-polyethylene glycol (LZM-PEG) dynamic hydrogel, we elucidated the mechanism whereby enhanced network dynamics activate early cell mechanotransduction via the integrin-FAK signaling axis, promoting nascent protein deposition which subsequently drives directed cell m

SUBMITTER: Shi S 

PROVIDER: S-EPMC12597304 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature