Aberrant striatal firing mediates impulsive decision-making in a mouse model of Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is characterized by progressive neurodegeneration, which is associated with motor and non-motor symptoms. Dopamine replacement therapy can remediate motor symptoms, but can also cause impulse control disorder (ICD), characterized by pathological gambling, hypersexuality and/or compulsive shopping. Approximately 14%-40% of all medicated PD patients suffer from ICD. Despite the high prevalence of ICD in medicated PD patients, we know little of its mechanisms, and the main therapeutic strategy is reducing or eliminating dopamine agonist medication. Human imaging studies suggest that the input nucleus of the basal ganglia, the striatum, may be a critical site of circuit dysfunction in ICD. To explore the cellular and circuit mechanisms of ICD, we developed a mouse mode

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC12597312 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature