Effect of intraoperative paravertebral or intravenous lidocaine infusion on postoperative complications and inflammation after lung resection surgery: a randomised controlled trial.

ABSTRACT:

Background

The potential for the anti-inflammatory effects of lidocaine to reduce complications after lung resection has not been evaluated. We assessed whether intraoperative i.v. or paravertebral lidocaine, compared with remifentanil, reduced complications after lung resection. We also quantified pulmonary and systemic inflammatory responses.

Methods

This single-centre study randomised participants undergoing lung resection (video-assisted thoracoscopy) to receive continuous infusion of either (1) i.v. lidocaine and paravertebral saline, (2) paravertebral lidocaine and i.v. saline, or (3) remifentanil and paravertebral saline. The primary outcome was the proportion of participants with all-cause complications (Clavien-Dindo classification). Cytokines were measured in bronc

SUBMITTER: de la Gala F 

PROVIDER: S-EPMC12597338 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature