Use of prothrombin complex concentrates in liver transplantation: a systematic review and meta-analysis.

ABSTRACT:

Background

Liver transplantation (LT) can be a high transfusion procedure. Frozen plasma (FP) is widely used despite mixed efficacy and safety data. Several centres perform LT with no or low volume of FP by using prothrombin complex concentrate (PCC). This systematic review and meta-analysis characterises the existing efficacy and safety data of PCC use in LT.

Methods

This review was registered (PROSPERO CRD#42024561866). MEDLINE, Embase, Cochrane, and ClinicalTrials.gov were searched from inception to 30 May 2024. Studies in adults undergoing LT where PCC exposure was reported in relation to clinical outcomes were included. Random effects models were used to obtain pooled effect estimates.

Results

All studies were retrospective, with seven reporting the number of pat

SUBMITTER: Kojundzic I 

PROVIDER: S-EPMC12597362 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature