Association of preoperative nocturnal hypoxaemia nadir and fentanyl ventilatory sensitivity in children with obstructive sleep apnoea undergoing general anaesthesia: a multicentre clinical cohort study.

ABSTRACT:

Background

Obstructive sleep apnoea (OSA) has been thought to increase the risk of respiratory depression from opioids. The primary aim of this study was to assess whether preoperative hypoxaemia by sleep study pulse oximetry imparts greater opioid sensitivity.

Methods

A multicentre observational cohort study with in-cohort dose randomisation was performed in children 2-8 yr of age with OSA undergoing adenotonsillectomy. Ninety patients were assigned to one of two Spo₂ cohorts by preoperative sleep study Spo₂ nadir of < or ≥85% to receive fentanyl 1.0 or 1.5 μg kg^-1 (maximum 25 μg) after sevoflurane induction. The primary outcome was the extent of opioid-induced central ventilatory depression over time by Spo₂ status as defined by

SUBMITTER: Adler AC 

PROVIDER: S-EPMC12597378 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature