Impact of neuromuscular block monitoring and reversal on postoperative pulmonary complications in thoracic surgery: a Bayesian analysis of the iPROVE-OLV trial.

ABSTRACT:

Background

Postoperative pulmonary complications (PPCs) are a significant concern in thoracic surgery. A modifiable factor influencing PPCs is postoperative residual neuromuscular block (NMB), which impairs respiratory muscle function.

Methods

We performed a post hoc Bayesian analysis of data from the iPROVE-OLV study, a multicentre randomised controlled trial involving patients undergoing thoracic surgery with one-lung ventilation. We compared participants managed with any neuromuscular monitoring and any reversal vs those managed without either. The primary outcome was the occurrence of a composite of PPCs within the first 7 postoperative days.

Results

Of the 698 patients included, 657 received any neuromuscular monitoring and any reversal, while 41 did not. Patient

SUBMITTER: Mazzinari G 

PROVIDER: S-EPMC12597387 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature