Neuropsychiatric symptoms and emerging dementia in people with Down syndrome and older adults.

ABSTRACT:

Introduction

Neuropsychiatric symptoms (NPS) are common as Alzheimer's disease (AD) dementia emerges, both in older adults (OA) and in individuals with Down syndrome (DS).

Methods

We compared neuropsychiatric inventory (NPI) scores and NPI score trajectories in large cohorts of individuals with DS and OA. Participants were stratified as cognitively normal/stable, mild cognitive impairment, or dementia.

Results

The pattern of NPI domain scores in cohorts with DS (n = 396) or OA (n = 35,217) were qualitatively similar across the cognitive groups. The relationships between cognitive group and both the NPI total score and the rate of NPI score change over time were similar in the two cohorts (multivariate Wald test, p = 0.28 and p = 0.52, respectively).

Discussion

SUBMITTER: Magana-Ramirez CM 

PROVIDER: S-EPMC12597398 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature