Racial disparities in hepatocellular carcinoma: a TCGA-based gene expression study of Caucasian and Asian populations.

ABSTRACT:

Aim

Hepatocellular carcinoma (HCC) displays both shared and ethnicity-specific molecular characteristics. Using transcriptomic data from The Cancer Genome Atlas (TCGA), we compared gene expression profiles between Asian and Caucasian HCC patients.

Methods

Gene expression profiles were analyzed using the PyDESeq2 implementation of DESeq2, applying size factor normalization and dispersion estimation. Differentially expressed genes (DEGs) were identified with thresholds of false discovery rate (FDR) of < 0.05 and |log₂FC| ≥ 1.0. Gene annotation, visualization, and pathway enrichment were conducted using Sanbomics, seaborn, and gene set enrichment analysis (GSEA) via the GSEApy package.

Results

A total of 387 and 250 genes were commonly upregulated and downregu

SUBMITTER: Rasyak MR 

PROVIDER: S-EPMC12597399 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature