Effect of intraoperative dexmedetomidine on prognosis in patients with cancer undergoing surgical procedures: a systematic review and meta-analysis.

ABSTRACT:

Background

Cancer places a significant burden on patients and healthcare systems. Dexmedetomidine, an α₂ adrenergic agonist commonly used in anaesthesia, has potential effects on cancer biology. We systematically reviewed and analysed the impact of intraoperative dexmedetomidine on postoperative survival and tumour recurrence in patients with cancer.

Methods

We conducted a comprehensive search of PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure up to April 2024. Two researchers extracted data including authors, year, country, study design, follow-up, patient characteristics, and hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival and recurrence-free survival. Quality assessment was conducted using the Cochran

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12597423 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature