Association of Physical Frailty With Incidence and Life Expectancy of COPD: A Population-Based Cohort Study.

ABSTRACT:

Background

The bidirectional relationship between frailty and COPD is documented. However, longitudinal studies examining the combined effects of genetic predisposition and preserved ratio impaired spirometry (PRISm) on frailty in COPD development are lacking.

Research question

What is the association between physical frailty and the incidence and mortality of COPD, and how do genetic predisposition and PRISm modify this association?

Study design and methods

We included 412,351 adults without COPD (mean age ± SD, 56.1 ± 8.1 years; 44.3% male) and 60,584 patients with COPD (mean age ± SD, 59.2 ± 7.4 years; 55.1% male) at baseline in the UK Biobank cohort. Frailty phenotypes were assessed using 5 components, including weight loss, exhaustion, low physical activity, slow

SUBMITTER: Liu C 

PROVIDER: S-EPMC12597428 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature