Altered Effective Connectivity Within a Thalamocortical Corollary Discharge Network in Individuals With Schizophrenia.

ABSTRACT:

Background and hypothesis

Sequential saccade planning requires corollary discharge (CD) signals that provide information about the planned landing location of an eye movement. These CD signals may be altered among individuals with schizophrenia (SZ), providing a potential mechanism to explain passivity and anomalous self-experiences broadly. In healthy controls (HC), a key oculomotor CD network transmits CD signals from the thalamus to the frontal eye fields (FEF) and the intraparietal sulcus (IPS) and also remaps signals from FEF to IPS.

Study design

Here, we modeled fMRI data using dynamic causal modeling (DCM) to examine patient-control differences in effective connectivity evoked by a double-step (DS) task (30 SZ, 29 HC). The interrogated network was formed from a combin

SUBMITTER: Lehet M 

PROVIDER: S-EPMC12597492 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature