Breastfeeding after breast cancer in young BRCA carriers.

ABSTRACT:

Background

We investigated safety of breastfeeding after breast cancer in patients carrying germline BRCA pathogenic or likely pathogenic variants.

Methods

This was an international, multicenter, hospital-based, retrospective cohort study including BRCA carriers diagnosed with stage I-III invasive breast cancer at age 40 years or younger between January 2000 and December 2020 (NCT03673306). Locoregional recurrences and/or contralateral breast cancers, disease-free survival (DFS), and overall survival (OS) were compared between patients who breastfed after delivery and those who did not.

Results

Among 4732 patients included from 78 centers worldwide, 659 had a pregnancy after breast cancer diagnosis, of whom 474 delivered a child. After excluding patients with uptake o

SUBMITTER: Blondeaux E 

PROVIDER: S-EPMC12597514 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature