A computational model of radial scaffolds in the human fetal brain based on MRI.

ABSTRACT: The organization of the human cerebral cortex during fetal development is regulated by multiple processes, including neurogenesis and neuronal migration, which are essential for cortical expansion and folding patterns. According to the radial unit hypothesis, neurons originate in the germinal zone and migrate radially along the radial glial scaffolds to reach the cortical plate. However, the spatial distributions of these scaffolds and their roles in cortical folding remain unclear. Consequently, a computational model was developed to simulate virtual scaffolds extending from the cerebral ventricular surface to the white matter, incorporating region-specific neurogenic potential. The results demonstrate dense scaffold distribution in the perisylvian region, where complex cortical folding e

SUBMITTER: Homae F 

PROVIDER: S-EPMC12597517 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature