Serum concentrations of perfluoroalkyl and polyfluoroalkyl substances and risk of ovarian cancer.

ABSTRACT:

Background

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent, widespread environmental contaminants, and some are endocrine disrupting. Studies of gynecologic cancers are limited; we evaluated ovarian cancer, a rare, often fatal malignancy.

Methods

This nested case-control study included 318 ovarian cancer cases and 472 individually matched female controls in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, which recruited participants aged 55-74 years from 10 US study centers (1993-2001). We looked at cases through 2016 and quantitated 8 PFAS in prediagnostic serum samples. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for continuous (log2-transformed) and categorized PFAS concentrations by using conditional logistic r

SUBMITTER: Jones RR 

PROVIDER: S-EPMC12597518 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature