Heterogeneous nuclear ribonucleoprotein A/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3β-Wnt pathway.

ABSTRACT: Gastric cancer (GC) is a leading cause of cancer-related deaths globally, with metastasis critically impacting prognosis. Splicing factors are key regulators of tumorigenesis, particularly in metastasis. In this exploratory study, we investigated the role and mechanism of heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) in GC cell invasion and migration. We detected a 3.45-fold increase in HNRNPAB protein levels in highly metastatic MKN45 cells compared with low metastatic MKN7 cells (P < .01) and marked upregulation in human GC tissues (n = 408) versus normal tissues (n = 211, P < .05, predicted by gene expression profiling interactive analysis). HNRNPAB overexpression in MKN45 and MKN7 cells substantially enhanced proliferation by 50% (P < .001, 3-[4,5-dimethyl-2-thiazolyl]-2,5-diph

SUBMITTER: Huiru L 

PROVIDER: S-EPMC12597541 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature